Michael Strupp Selected Research

Cerebellar Ataxia (Dysmetria)

4/2022	Consensus Paper: Ataxic Gait.
12/2021	Safety and Efficacy of Acetyl-DL-Leucine in Certain Types of Cerebellar Ataxia: The ALCAT Randomized Clinical Crossover Trial.
4/2020	Beneficial Effects of Acetyl-DL-Leucine (ADLL) in a Mouse Model of Sandhoff Disease.
1/2019	Aminopyridines and Acetyl-DL-leucine: New Therapies in Cerebellar Disorders.
1/2017	Effects of acetyl-DL-leucine on cerebellar ataxia (ALCAT trial): study protocol for a multicenter, multinational, randomized, double-blind, placebo-controlled, crossover phase III trial.
4/2016	Update on the pharmacotherapy of cerebellar and central vestibular disorders.
2/2016	Update on the Pharmacotherapy of Cerebellar Ataxia and Nystagmus.
1/2016	Acetyl-DL-leucine improves gait variability in patients with cerebellar ataxia-a case series.
10/2015	Acetyl-dl-leucine in Niemann-Pick type C: A case series.
4/2015	Pharmacotherapy of vestibular and cerebellar disorders and downbeat nystagmus: translational and back-translational research.

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Michael Strupp Research Topics

Disease

18	Type 2 Episodic Ataxia 08/2021 - 02/2006
17	Vertigo (Positional Vertigo) 10/2021 - 05/2008
14	Vestibular Neuronitis (Vestibular Neuritis) 01/2018 - 07/2004
12	Cerebellar Ataxia (Dysmetria) 04/2022 - 09/2011
9	Ataxia (Dyssynergia) 12/2021 - 03/2011
9	Migraine Disorders (Migraine) 12/2019 - 03/2011
8	Multiple Sclerosis 04/2013 - 08/2004
7	Meniere Disease (Menieres Disease) 01/2016 - 02/2006
6	Dizziness (Lightheadedness) 10/2021 - 05/2009
6	Cerebellar Diseases (Cerebellar Syndrome) 01/2019 - 01/2008
5	Nervous System Diseases (Neurological Disorders) 06/2022 - 04/2007
5	Gait Ataxia 01/2019 - 11/2012
5	Stroke (Strokes) 01/2017 - 09/2009
5	Pathologic Nystagmus 01/2017 - 02/2006
4	Infections 08/2020 - 12/2003
4	Motor Disorders 01/2019 - 02/2006
3	Disease Progression 01/2021 - 07/2007
3	Sandhoff Disease (Sandhoff's Disease) 01/2021 - 04/2020
3	Type C Niemann-Pick Disease (Niemann Pick Disease, Type C) 01/2021 - 07/2020
3	Bilateral Vestibulopathy 02/2013 - 08/2005
2	Paresthesia (Dysesthesia) 08/2021 - 01/2017
2	Fatigue 08/2021 - 01/2017
2	Neurodegenerative Diseases (Neurodegenerative Disease) 06/2021 - 01/2021
2	Benign Paroxysmal Positional Vertigo 01/2021 - 04/2015
2	Lysosomal Storage Diseases (Lysosomal Storage Disease) 01/2021 - 04/2020
2	Spinocerebellar Ataxias (Spinocerebellar Ataxia) 01/2017 - 10/2013
2	Tremor (Tremors) 01/2017 - 04/2013
2	Headache (Headaches) 01/2017 - 06/2015
2	Trochlear Nerve Diseases (Fourth Nerve Palsy) 07/2016 - 03/2011
2	Endolymphatic Hydrops 10/2014 - 02/2013
2	Episodic Ataxia 09/2011 - 06/2005
2	Congenital Nystagmus 07/2011 - 03/2011
2	Atrial Fibrillation 07/2010 - 01/2005
2	Parkinson Disease (Parkinson's Disease) 04/2010 - 12/2009
2	Absence Epilepsy (Childhood Absence Epilepsy) 04/2010 - 06/2005
2	Meningitis 05/2009 - 06/2007
1	Restless Legs Syndrome (Restless Legs) 07/2021
1	Splenomegaly 06/2021
1	Gaucher Disease (Gaucher's Disease) 06/2021
1	Motor Neuron Disease (Primary Lateral Sclerosis) 06/2021
1	Dystonia (Limb Dystonia) 06/2021
1	Dementia (Dementias) 06/2021
1	Parkinsonian Disorders (Parkinsonism) 06/2021
1	GM2 Gangliosidoses (GM2 Gangliosidosis) 01/2021
1	Vestibular Diseases 01/2021
1	Diplopia (Double Vision) 12/2020
1	Cytokine Release Syndrome 08/2020
1	Ganglion Cysts (Ganglion) 07/2020

Drug/Important Bio-Agent (IBA)

16	acetylleucineIBA 12/2021 - 07/2013
15	AminopyridinesIBA 01/2019 - 02/2006
12	Betahistine (Serc)IBA 10/2018 - 02/2006
11	4-Aminopyridine (4 Aminopyridine)FDA Link 08/2021 - 09/2011
11	Adrenal Cortex Hormones (Corticosteroids)IBA 07/2013 - 07/2004
7	Pharmaceutical PreparationsIBA 12/2021 - 07/2011
6	Amino Acids FDA Link 01/2019 - 10/2013
6	Calcium Channels (Calcium Channel)IBA 01/2019 - 06/2005
6	Potassium Channel Blockers (Blockers, Potassium Channel)IBA 02/2017 - 03/2008
6	Carbamazepine (Tegretol)FDA LinkGeneric 04/2016 - 07/2009
6	Gabapentin (Neurontin)FDA LinkGeneric 04/2016 - 02/2006
5	Acetazolamide (Diamox)FDA LinkGeneric 08/2021 - 04/2015
5	Metoprolol (Toprol-XL)FDA LinkGeneric 12/2019 - 03/2011
5	Baclofen FDA LinkGeneric 04/2016 - 02/2006
5	Memantine (Namenda)FDA Link 07/2013 - 02/2006
4	Proteins (Proteins, Gene)FDA Link 01/2018 - 06/2012
4	Anticonvulsants (Antiepileptic Drugs)IBA 04/2016 - 04/2010
3	Vitamin D FDA LinkGeneric 01/2021 - 04/2011
3	Leucine (L-Leucine)FDA Link 01/2021 - 01/2015
3	Oxcarbazepine (Trileptal)FDA LinkGeneric 04/2016 - 07/2011
3	Chlorzoxazone FDA LinkGeneric 04/2016 - 07/2013
3	AminoglycosidesIBA 03/2013 - 06/2007
3	AntibodiesIBA 06/2012 - 07/2005
2	Biomarkers (Surrogate Marker)IBA 04/2022 - 12/2010
2	Glucosylceramidase (Glucocerebrosidase)IBA 06/2021 - 12/2009
2	Selective Serotonin Reuptake Inhibitors (Serotonin Reuptake Inhibitors)IBA 01/2020 - 03/2011
2	Insulin (Novolin)FDA Link 01/2018 - 07/2010
2	Topiramate (Topamax)FDA LinkGeneric 04/2016 - 03/2011
2	Antidepressive Agents (Antidepressants)IBA 06/2015 - 04/2015
2	Histamine (Histamine Dihydrochloride)FDA Link 01/2015 - 10/2014
2	Ion Channels (Ion Channel)IBA 10/2013 - 09/2011
2	Gentamicins (Gentamicin)FDA LinkGeneric 03/2011 - 02/2006
2	RNA (Ribonucleic Acid)IBA 11/2009 - 07/2005
2	Methylprednisolone FDA LinkGeneric 03/2005 - 07/2004
2	Mitoxantrone (Novantrone)FDA LinkGeneric 01/2005 - 08/2004
1	Complement System Proteins (Complement)IBA 06/2022
1	Essential Amino AcidsIBA 12/2021
1	Levodopa (L Dopa)FDA LinkGeneric 06/2021
1	Filipin (Filipin III)IBA 06/2021
1	LipidsIBA 01/2021
1	25-hydroxyvitamin DIBA 01/2021
1	hydroxide ionIBA 01/2021
1	Neuroprotective AgentsIBA 01/2021
1	Immunosuppressive Agents (Immunosuppressants)IBA 08/2020
1	Retinaldehyde (Retinal)IBA 07/2020

Therapy/Procedure

16	Therapeutics 06/2022 - 08/2004
8	Drug Therapy (Chemotherapy) 01/2019 - 01/2010
2	Occupational Therapy (Therapy, Occupational) 02/2020 - 01/2017
1	Duration of Therapy 12/2021
1	Off-Label Use 01/2021
1	Treatment Delay 01/2021
1	Telescopes 12/2020